Why the study?
Does captopril administration alter circulating levels of angiotensin I, angiotensin II, bradykinin, and renin?
Population
8 normal subjects, 1 patient with proved renovascular hypertension, and 1 anaesthetized dog
Comparison
Captopril 50 mg single dose vs Baseline measurements before administration
Design
Other
Follow-up
120 minutes
Authors
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Associates captopril hypotension with RAS changes without bradykinin rise; leaves open tissue-level or agent-specific bradykinin roles.
Does captopril administration alter circulating levels of angiotensin I, angiotensin II, bradykinin, and renin?
The hypotensive effect of captopril is associated with changes in the renin-angiotensin system but not with increased circulating bradykinin levels.
Millar et al. (1979) studied this question.
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