Why the study?
Does captopril alter blood levels of angiotensin I, plasma renin activity, and bradykinin in normal Sprague-Dawley rats?
Population
Normal Sprague-Dawley rats
Design
Preclinical
Follow-up
60 minutes
Authors
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These rat data support primary RAS inhibition by captopril; human bradykinin effects at therapeutic doses remain untested.
Does captopril alter blood levels of angiotensin I, plasma renin activity, and bradykinin in normal Sprague-Dawley rats?
Captopril primarily acts by inhibiting the circulating renin-angiotensin system, with an added effect on the kallikrein-kinin system at higher doses.
Matthews et al. (1979) studied this question.
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