Why the study?
Does a single dose of captopril increase plasma bradykinin in patients with renin-independent essential hypertension?
Population
21 patients with renin-independent essential hypertension who showed agonistic pressor responses to 1Sar…
Design
Cohort
Follow-up
90 minutes
Authors
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Supports kinin role in ACEI response in renin-independent hypertension; hypothesis-generating and requires randomized confirmation before clinical inference.
Does a single dose of captopril increase plasma bradykinin in patients with renin-independent essential hypertension?
In patients with renin-independent essential hypertension, the acute hypotensive effect of captopril is associated with an increase in plasma bradykinin, suggesting kinins play a role in its mechanism of action.
Miyamori et al. (1983) studied this question.
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