Why the study?
Does captopril reduce stimulation-evoked norepinephrine release in rat central nervous system slices?
Population
Slices of rat hypothalamus and medulla oblongata prelabelled with [3H]-norepinephrine
Comparison
Captopril (1 x 10 mol/L, 3.3 x 10 mol/L, and 5 x… vs Control (Krebs-Ringer solution)
Design
Preclinical
Authors
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Suggests central sympathoinhibitory effects of ACE inhibitors; leaves open translation to human cardiovascular outcomes.
Does captopril reduce stimulation-evoked norepinephrine release in rat central nervous system slices?
Captopril inhibits stimulation-evoked norepinephrine release in the rat hypothalamus and medulla oblongata, suggesting a central neurosuppressive mechanism for ACE inhibitors.
Tsuda et al. (1995) studied this question.
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