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September 1, 1981Clinical Science

Captopril Attenuates Adrenergic Vasoconstriction in Rat Mesenteric Arteries by Angiotensin-Dependent and -Independent Mechanisms

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Key result

Captopril blunts angiotensin I-potentiated sympathetic nerve stimulation and directly antagonizes noradrenaline in rat arteries.

Why the study?

Does captopril attenuate adrenergic vasoconstriction in isolated rat mesenteric arteries?

Population

Isolated, Krebs-Ringer solution perfused, rat mesenteric arteries

Comparison

Captopril at low and high concentrations vs Baseline responses in the absence of captopril…

Design

Preclinical

Authors

MCM G CollisAstraZeneca (United Kingdom)JKJ R KeddieAstraZeneca (United Kingdom)

Discussion

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Overview

Captopril's dual actions in rat arteries should not yet inform clinical dosing; leaves open whether angiotensin-independent effects occur at therapeutic concentrations in humans.

Structured PICO

Does captopril attenuate adrenergic vasoconstriction in isolated rat mesenteric arteries?

P
Population
Isolated, Krebs-Ringer solution perfused, rat mesenteric arteries
I
Intervention
Captopril (SQ 14 225) at low (2 x 10^-6 mol/l) and high (1 x 10^-4 to 3 x 10^-4 mol/l) concentrations
C
Comparator
Baseline responses in the absence of captopril or exogenous peptides
O
Outcome
Vasoconstrictor response evoked by sympathetic nerve stimulation and exogenous noradrenalinesurrogate

Captopril attenuates sympathetic vasoconstriction through both angiotensin-dependent mechanisms at low concentrations and angiotensin-independent mechanisms at high concentrations.

Cite This Study

Collis et al. (1981) studied this question. Captopril was evaluated on Vasoconstrictor response evoked by sympathetic nerve stimulation. In isolated rat mesenteric arteries, captopril antagonized the potentiating effect of angiotensin I on sympathetic nerve stimulation and, at high concentrations, directly antagonized responses to noradrenaline.

synapsesocial.com/papers/6aa2160b53426e2d6db2b0e5https://doi.org/10.1042/cs0610281
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Captopril Interferes with Neurogenic Vasoconstriction in the Pithed Rat by Angiotensin-Dependent Mechanisms1982 · 80 citations
  2. 2Interference by Inhibitors of the Renin-Angiotensin System with Neurogenic Vasoconstriction1983 · 18 citations
  3. 3Effects of captopril on vascular reactivity of SHR in vivo and in vitro.1981 · 28 citations
  4. 4EFFECTS OF CAPTOPRIL ON [3H]‐NOREPINEPHRINE RELEASE IN RAT CENTRAL NERVOUS SYSTEM1995 · 4 citations
  5. 5Effect of captopril on vasoconstriction and Ca2+ fluxes in aortic smooth muscle.1993 · 22 citations