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January 1, 1982Journal of Cardiovascular Pharmacology

Captopril Interferes with Neurogenic Vasoconstriction in the Pithed Rat by Angiotensin-Dependent Mechanisms

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Key result

ACE inhibitors captopril and SQ20881 reduced vasoconstrictor responses to nerve stimulation and exogenous noradrenaline in pithed rats via an angiotensin-dependent mechanism.

Population

Pithed rat preparation (including a subset bilaterally nephrectomized 18-24 h previously)

Design

Preclinical

Authors

RHR HattonOrlando HealthDCD.P. CloughHannah Research Foundation

Discussion

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Overview

May blunt sympathetic vasoconstriction; leaves open mechanistic relevance to human ACE inhibitor therapy.

Structured PICO

P
Population
Pithed rat preparation used to investigate the effect of ACE inhibitors on neurogenic vasoconstriction.
I
Intervention
Captopril (0.1 and 1 mg/kg), SQ20881 (10 mg/kg), or [Sar1 Ala8]angiotensin II (4 micrograms/kg/min)
O
Outcome
Vasoconstrictor responses to nerve stimulation (1-30 Hz) and exogenous noradrenaline (10-500 ng)surrogate

ACE inhibitors lower blood pressure partly by interfering with neurogenic vasoconstriction via an angiotensin-dependent mechanism.

Cite This Study

Hatton et al. (1982) studied this question. ACE inhibitors (captopril and SQ20881) was evaluated on Vasoconstrictor responses to nerve stimulation and exogenous noradrenaline. ACE inhibitors captopril and SQ20881 reduced vasoconstrictor responses to nerve stimulation and exogenous noradrenaline in pithed rats via an angiotensin-dependent mechanism.

synapsesocial.com/papers/6a6da64b439bab0cabc29516https://doi.org/10.1097/00005344-198201000-00019
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Interference by Inhibitors of the Renin-Angiotensin System with Neurogenic Vasoconstriction1983 · 18 citations
  2. 2Captopril Attenuates Adrenergic Vasoconstriction in Rat Mesenteric Arteries by Angiotensin-Dependent and -Independent Mechanisms1981 · 38 citations
  3. 3Pre- and postjunctional inhibition of vascular sympathetic function by captopril in SHR. Implication of vascular angiotensin II in hypertension and antihypertensive actions of captopril.1981 · 129 citations
  4. 4Effects of Captopril on Neurosecretion and Vascular Responsiveness in Hypertension1987 · 7 citations
  5. 5ATTENUATION BY CAPTOPRIL OF PRESSOR RESPONSES TO SYMPATHETIC STIMULI: EFFECTS OF PROCEDURES REDUCING ACTIVITY OF THE RENIN‐ANGIOTENSIN SYSTEM1983 · 7 citations