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September 1, 1983Journal of Autonomic Pharmacology

Attenuation by Captopril of Pressor Responses to Sympathetic Stimuli: Effects of Procedures Reducing Activity of the Renin‐angiotensin System

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Population

Pithed rats

Comparison

Intravenous captopril (0.1-5.0 mg/kg) vs Baseline or various physiological states

Design

Preclinical

Authors

ABA.L.A. BouraMonash UniversityMRM. P. RechtmanSt Vincents Institute of Medical ResearchWWW.A.W. WaltersRoyal Hospital for Women

Discussion

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Implication

Hypothesis-generating for RAS-dependent sympathetic modulation in rats; leaves open human translation and should not change practice.

Structured PICO

P
Population
Pithed rats
I
Intervention
Intravenous captopril (0.1-5.0 mg/kg)
C
Comparator
Baseline or various physiological states (e.g., bilateral nephrectomy, unilateral nephrectomy, beta-adrenoreceptor blockade)
O
Outcome
Systolic and diastolic arterial blood pressures and pressor responses to sympathetic stimulisurrogate

Captopril attenuates pressor responses to sympathetic stimuli in pithed rats, an effect dependent on the basal activity of the renin-angiotensin system.

Cite This Study

Boura et al. (1983) studied this question.

synapsesocial.com/papers/6a8334f65b5082326951ba74https://doi.org/10.1111/j.1474-8673.1983.tb00536.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Attenuation of pressor responses to norepinephrine and pitressin and potentiation of pressor response to angiotensin II by captopril in human subjects.1982 · 45 citations
  2. 2Interference by Inhibitors of the Renin-Angiotensin System with Neurogenic Vasoconstriction1983 · 18 citations
  3. 3Influence of Angiotensin Converting Enzyme Inhibition with Captopril on Blood Pressure and Adrenergic Function in Normal and Sodium Restricted Rats1981 · 6 citations
  4. 4Effects of captopril on vascular reactivity of SHR in vivo and in vitro.1981 · 28 citations
  5. 5Effects of chronic administration of captopril on blood pressure and the renin-angiotensin-aldosterone system in normotensive rats.1983 · 9 citations