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May 1, 1981Hypertension

Pre- and postjunctional inhibition of vascular sympathetic function by captopril in SHR. Implication of vascular angiotensin II in hypertension and antihypertensive actions of captopril.

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Key result

Captopril selectively inhibited vascular pressor responses to sympathetic nerve stimulation in SHR without affecting cardiac responses, likely via inhibition of local angiotensin II formation.

Why the study?

Does captopril inhibit vascular and cardiac responses to sympathetic nerve stimulation in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHR) (pithed SHR)

Design

Preclinical

Follow-up

Up to 6 months

Authors

MAMichael J. AntonaccioUniversity of DundeeLKLinda KerwinNovartis (Switzerland)

Discussion

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Implication

Supports local angiotensin II modulation of sympathetic tone in hypertension models; leaves open translation to human therapy.

Key Points

  • This study aims to assess the effects of captopril on vascular and cardiac responses to sympathetic stimulation in SHR.
  • Investigated effects of captopril (10 mg/kg i.v. and 10-100 mg/kg p.o.), teprotide, and saralasin in SHR.
  • Measured responses to sympathetic nerve stimulation and angiotensin I, angiotensin II, and norepinephrine.
  • Evaluated chronic captopril treatment over 2 weeks, 3 months, and 6 months.
  • Captopril significantly inhibited pressor responses to sympathetic stimulation (p<0.01).
  • Responses to angiotensin I were abolished, while responses to angiotensin II and norepinephrine remained unchanged.
  • Combination of indomethacin pretreatment and angiotensin II infusion restored sympathetic function.

Structured PICO

Does captopril inhibit vascular and cardiac responses to sympathetic nerve stimulation in spontaneously hypertensive rats?

P
Population
Spontaneously Hypertensive Rats (SHR) treated with captopril, teprotide, and saralasin to examine vascular and cardiac responses.
I
Intervention
Captopril (single dose 10 mg/kg i.v., 10 and 100 mg/kg p.o.; chronic daily oral doses for 2 weeks, 3 and 6 months), teprotide, and saralasin
O
Outcome
Vascular and cardiac responses to sympathetic nerve stimulation and angiotensin I and II (AI, AII) and norepinephrine (NE)surrogate

Captopril selectively inhibits vascular, but not cardiac, responses to sympathetic nerve stimulation in spontaneously hypertensive rats, likely via inhibition of local vascular angiotensin II formation.

Cite This Study

Antonaccio et al. (1981) studied Hypertension. Captopril vs. Teprotide and saralasin was evaluated on Vascular and cardiac responses to sympathetic nerve stimulation, angiotensin I and II, and norepinephrine. Captopril selectively inhibited vascular pressor responses to sympathetic nerve stimulation in SHR without affecting cardiac responses, likely via inhibition of local angiotensin II formation.

synapsesocial.com/papers/6a227e80ffccceb004b72f17https://doi.org/10.1161/01.hyp.3.3_pt_2.i54

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oral Angiotensin-Converting Enzyme Inhibitor in Long-Term Treatment of Hypertensive Patients1979 · 356 citations
  2. 2Sympathoadrenal and renin-angiotensin systems in the development of two-kidney, one clip renal hypertension in rats.1980 · 20 citations
  3. 3Vascular renin-like activity and blood pressure maintenance in the rat. Studies of the effect of changes in sodium balance, hypertension and nephrectomy.1979 · 105 citations
  4. 4Effect of Angiotensin on the Cardioaccelerator Response to Sympathetic Nerve Stimulation in Isolated Rabbit Hearts1970 · 20 citations
  5. 5Angiotensin-Sodium Interaction in Blood Pressure Maintenance of Renal Hypertensive and Normotensive Rats1973 · 291 citations