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September 1, 1984HypertensionOpen Access

Effects of captopril on vascular noradrenergic transmission in SHR.

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Why the study?

Does captopril alter vascular noradrenergic transmission in spontaneously hypertensive rats compared to normotensive rats?

Population

Spontaneously hypertensive rats and normotensive Wistar-Kyoto rats

Comparison

Captopril 3 mg/kg and 10 mg/kg vs Normotensive Wistar-Kyoto rats and baseline…

Design

Preclinical

Authors

DEDouglas C. EikenburgUniversity of Houston

Discussion

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Overview

Captopril exerts similar postjunctional sympathoinhibition in SHR and WKY; leaves open its role in differential antihypertensive efficacy in humans.

Structured PICO

Does captopril alter vascular noradrenergic transmission in spontaneously hypertensive rats compared to normotensive rats?

P
Population
Spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY) (mesenteric vascular beds perfused in situ)
I
Intervention
Captopril 3 mg/kg and 10 mg/kg
C
Comparator
Normotensive Wistar-Kyoto rats (WKY) and baseline responses
O
Outcome
Mean arterial blood pressure (MAP), frequency-response curve to sympathetic nerve stimulation, and dose-response curve to norepinephrine (NE)surrogate

Captopril lowers blood pressure more effectively in hypertensive rats, but its effects on vascular neurotransmission appear postjunctional and similar in both hypertensive and normotensive models.

Cite This Study

Douglas C. Eikenburg (1984) studied this question.

synapsesocial.com/papers/6a76517270b84e52bb88017ahttps://doi.org/10.1161/01.hyp.6.5.660
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Captopril Attenuates Adrenergic Vasoconstriction in Rat Mesenteric Arteries by Angiotensin-Dependent and -Independent Mechanisms1981 · 38 citations
  2. 2Vascular wall renin in spontaneously hypertensive rats. Potential relevance to hypertension maintenance and antihypertensive effect of captopril.1982 · 143 citations
  3. 3Captopril Interferes with Neurogenic Vasoconstriction in the Pithed Rat by Angiotensin-Dependent Mechanisms1982 · 80 citations
  4. 4Hypotensive action of captopril and saralasin in intact and anephric spontaneously hypertensive rats.1980 · 38 citations
  5. 5Renin in Rats with Spontaneous Hypertension1972 · 132 citations