Why the study?
Does captopril alter the pressor responses to norepinephrine, angiotensin II, and pitressin in normal male volunteers?
Population
38 normal male volunteers aged 20 to 35 years
Comparison
Captopril 50 mg by mouth vs Baseline responses before captopril treatment
Design
Other
Follow-up
10 minutes per infusion
Authors
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Does not support practice change in hypertension; leaves open translation of vasopressor interactions to patients.
Does captopril alter the pressor responses to norepinephrine, angiotensin II, and pitressin in normal male volunteers?
Captopril attenuates pressor responses to norepinephrine and pitressin primarily by depleting endogenous angiotensin II, which may desensitize arterial smooth muscle contraction.
Imai et al. (1982) studied this question.
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