Why the study?
Does captopril reduce systolic blood pressure in rats with early one-kidney, one-clip hypertension?
Population
Rats with one-kidney, one-clip hypertension of less than 3 weeks duration, and anephric rats
Comparison
Intraperitoneal injection of the… vs Normotensive controls and similarly…
Design
Preclinical
Authors
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Captopril lowers BP independently of renin in this rat model; leaves open non-RAS pathways in human renovascular hypertension.
Does captopril reduce systolic blood pressure in rats with early one-kidney, one-clip hypertension?
The study demonstrates that early one-kidney, one-clip hypertension in rats is not solely dependent on the renin-angiotensin system, as captopril lowers blood pressure even in anephric rats.
Vandongen et al. (1981) studied this question.
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