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October 1, 1992Clinical and Experimental Pharmacology and Physiology

Angiotensin‐converting Enzyme Inhibition Causes Deterioration in Renal Function in One‐kidney Goldblatt Hypertensive Rats With and Without Renal Arterial Stenosis

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Why the study?

Does cilazapril affect blood pressure and renal function in one-kidney Goldblatt hypertensive rats with and without renal arterial stenosis?

Population

36 rats

Comparison

Cilazapril infused intravenously vs Pre-infusion baseline

Design

Preclinical

Follow-up

Acute (during infusion)

Authors

WHWann‐Chu HuangNational Sun Yat-sen UniversityJWJiannan WuHubei Provincial Women and Children's HospitalJJJong‐Shiaw JinTungs' Taichung MetroHarbor Hospital

Discussion

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Implication

Cilazapril lowers BP but impairs GFR and natriuresis in 1K1C rats; leaves open relevance to human renovascular hypertension.

Structured PICO

Does cilazapril affect blood pressure and renal function in one-kidney Goldblatt hypertensive rats with and without renal arterial stenosis?

P
Population
36 rats (18 one-kidney, one-clip Goldblatt hypertensive [1K1C], 10 one-kidney normotensive [1K], and 8 1K1C with acute unclipping [1KU])
I
Intervention
Cilazapril infused intravenously (25 micrograms/kg per min)
C
Comparator
Pre-infusion baseline
O
Outcome
Arterial blood pressure and renal clearance (glomerular filtration rate, urine flow, sodium excretion)surrogate

In a rat model of renovascular hypertension, ACE inhibition with cilazapril lowered blood pressure but caused a pressure-associated reduction in renal function that persisted even after acute surgical correction of the stenosis.

Cite This Study

Huang et al. (1992) studied this question.

synapsesocial.com/papers/6a7160eb439bab0cabc38e30https://doi.org/10.1111/j.1440-1681.1992.tb00406.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antihypertensive and renal effects of cilazapril and their reversal by angiotensin in renovascular hypertensive rats1988 · 12 citations
  2. 2Decrease in Peripheral Sympathetic Nervous System Activity following Renal Denervation or Unclipping in the One-Kidney One-Clip Goldblatt Hypertensive Rat1982 · 112 citations
  3. 3Role of angiotensin II in experimental renal hypertension in the rabbit1975 · 24 citations
  4. 4Hypertension of Renal Origin: Evidence for Two Different Mechanisms1971 · 336 citations
  5. 5Inhibition of Angiotensin Conversion in Experimental Renovascular Hypertension1972 · 125 citations