Why the study?
Does antihypertensive treatment or clip removal improve the reactivity of resistance arteries to endothelin-1 in 2K, 1C Goldblatt hypertensive rats?
Does antihypertensive treatment or clip removal improve the reactivity of resistance arteries to endothelin-1 in 2K, 1C Goldblatt hypertensive rats?
ACE inhibition and clip removal, but not metoprolol or hydralazine, normalized the blunted reactivity of resistance arteries to endothelin-1 in a rat model of renovascular hypertension.
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ACE inhibition normalizes blunted ET-1 reactivity in Goldblatt hypertensive rat arteries unlike other agents; leaves open human translation.
Deng et al. (1993) studied this question.
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