November 1, 1990Hypertension
Effects of angiotensin converting enzyme inhibitors and of hydralazine on endothelial function in hypertensive rats.
Why the study?
Does long-term treatment with ACE inhibitors or hydralazine improve endothelial function in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (normotensive reference)
Comparison
Long-term treatment with cilazapril, captopril… vs Untreated spontaneously hypertensive rats
Design
Preclinical
Follow-up
long-term
Authors
Discussion
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Implication
ACEI endothelial benefits in hypertensive rat models are hypothesis-generating; clinical translation remains unproven.
Key Points
- This study aims to assess the effects of cilazapril and hydralazine on endothelial function in hypertensive rats.
- Spontaneously hypertensive rats (SHR) were treated with cilazapril or hydralazine.
- Aortic rings with or without endothelium were tested in organ chambers using norepinephrine and acetylcholine.
- Effects on vasoconstriction and morphology of the intima were evaluated in carotid arteries.
- Cilazapril treatment enhanced acetylcholine-induced relaxation to 8 +/- 4% versus 55 +/- 5% in untreated SHR (p<0.001).
- Hydralazine did not significantly alter endothelial function.
- Cilazapril prevented morphological changes in the intima, indicating protective effects against hypertension.
Structured PICO
Does long-term treatment with ACE inhibitors or hydralazine improve endothelial function in spontaneously hypertensive rats?
P
Population
Spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (normotensive reference)
I
Intervention
Long-term treatment with cilazapril (ACE inhibitor), captopril, or hydralazine
C
Comparator
Untreated spontaneously hypertensive rats
O
Outcome
Endothelium-dependent responses in isolated aortic rings (acetylcholine-induced relaxation and serotonin-induced constriction)surrogate
ACE inhibitors, but not hydralazine, prevent functional and morphological alterations in the endothelium of hypertensive rats, suggesting a mechanism for their antihypertensive efficacy.
Cite This Study
Clozel et al. (1990) studied this question.