Key result
Treatment with ACE inhibitors (perindopril or quinapril), but not hydralazine or amlodipine, prevented impaired endothelium-dependent relaxation in resistance arteries of hypertensive rats.
Why the study?
Does long-term treatment with perindopril, quinapril, hydralazine, or amlodipine improve endothelium-dependent relaxation in resistance arteries of spontaneously hypertensive rats?
Population
Three-week-old spontaneously hypertensive rats (SHRs)
Comparison
Perindopril, quinapril, hydralazine, or… vs Control SHRs and Wistar-Kyoto rats treated with…
Design
Preclinical
Follow-up
21 weeks
Authors
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ACE inhibitors may confer endothelial benefits beyond BP control in rats; leaves open translation to human hypertension management.
Does long-term treatment with perindopril, quinapril, hydralazine, or amlodipine improve endothelium-dependent relaxation in resistance arteries of spontaneously hypertensive rats?
ACE inhibitors, unlike hydralazine or amlodipine, restore endothelium-dependent relaxation in resistance arteries of spontaneously hypertensive rats, suggesting specific vascular benefits beyond blood pressure lowering.
Bennett et al. (1996) studied Hypertension (spontaneously hypertensive rats). perindopril, quinapril, hydralazine, or amlodipine vs. Water (untreated SHRs and WKY rats) was evaluated on Endothelium-dependent relaxation in resistance arteries. Treatment with ACE inhibitors (perindopril or quinapril), but not hydralazine or amlodipine, prevented impaired endothelium-dependent relaxation in resistance arteries of hypertensive rats.
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