Why the study?
Does acute or chronic hydralazine treatment restore endothelium-dependent relaxant responses in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR) and normotensive Wistar rats
Comparison
Hydralazine administered acutely or chronically vs Normotensive Wistar rats and/or untreated state
Design
Preclinical
Follow-up
15 days
Authors
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Supports reversibility of vascular changes in experimental hypertension; leaves open whether chronic vasodilators improve endothelial function in patients.
Does acute or chronic hydralazine treatment restore endothelium-dependent relaxant responses in spontaneously hypertensive rats?
Chronic, but not acute, administration of hydralazine restores impaired endothelium-dependent vasodilation in spontaneously hypertensive rats, suggesting that vascular alteration is reversible and not solely dependent on acute blood pressure reduction.
Nigro et al. (1989) studied this question.
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