What question did this study set out to answer?

This research aims to determine whether antihypertensive treatment can enhance endothelium-dependent hyperpolarization in spontaneously hypertensive rats.

July 14, 1998CirculationOpen Access

Antihypertensive Treatment Improves Endothelium-Dependent Hyperpolarization in the Mesenteric Artery of Spontaneously Hypertensive Rats

Q: What is the clinical evidence from this study?

Study design: Other. Population: Hypertension (Spontaneously hypertensive rats). Intervention: Enalapril or Hydralazine + Hydrochlorothiazide vs. Untreated spontaneously hypertensive rats and Wistar Kyoto rats. Primary outcome: Acetylcholine-induced hyperpolarization and EDHF-mediated relaxation in the mesenteric artery.

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Key result

Antihypertensive treatment with enalapril or hydralazine/hydrochlorothiazide improved EDHF-mediated maximal relaxation (79.3% and 47.4% vs 4.8%) in the mesenteric artery of hypertensive rats.

Why the study?

Does antihypertensive treatment improve EDHF-mediated hyperpolarization and relaxation in the mesenteric artery of spontaneously hypertensive rats?

Population

8- to 9-month-old spontaneously hypertensive rats (SHRs)

Comparison

Enalapril or a combination of hydralazine and… vs Age-matched untreated spontaneously hypertensive…

Design

Preclinical

Follow-up

3 months

Authors

UOUran OnakaHidaka Hospital KFKoji FujiiTokushima Red Cross Hospital IAIsao AbeAjinomoto (United States)

Discussion

Member takes

Implication

Antihypertensive restoration of EDHF hyperpolarization in SHR models merits human studies; leaves open direct clinical translation.

Key Points

This research aims to determine whether antihypertensive treatment can enhance endothelium-dependent hyperpolarization in spontaneously hypertensive rats.
Spontaneously hypertensive rats were treated with enalapril or a combination of hydralazine and hydrochlorothiazide for 3 months.
Control groups included age-matched spontaneously hypertensive rats and Wistar Kyoto rats.
Acetylcholine-induced hyperpolarization and relaxation responses were measured in mesenteric arteries.
Acetylcholine-induced hyperpolarization in treated SHRs improved to approximately -14.4 mV (SHR-E) and -12.0 mV (SHR-H) compared to -7.2 mV in untreated SHRs.
Maximal EDHF-mediated relaxation in treated SHRs was significantly higher at 79.3% (SHR-E) and 47.4% (SHR-H) compared to 4.8% in untreated SHRs.
No difference in relaxation to acetylcholine was observed when EDHF responses were eliminated, indicating specific improvement in EDHF pathways.

Structured PICO

Does antihypertensive treatment improve EDHF-mediated hyperpolarization and relaxation in the mesenteric artery of spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats aged 8 to 9 months treated with antihypertensive therapy for 3 months.

Intervention

Enalapril (40 mg/kg/d) or a combination of hydralazine (25 mg/kg/d) and hydrochlorothiazide (7.5 mg/kg/d) for 3 months

Comparator

Age-matched untreated spontaneously hypertensive rats (SHR-Cs) and normotensive Wistar Kyoto rats (WKYs)

Outcome

Acetylcholine-induced hyperpolarization and EDHF-mediated relaxation in the mesenteric arterysurrogate

Antihypertensive treatment improves EDHF-mediated endothelial function in the mesenteric arteries of spontaneously hypertensive rats, independent of the specific drug class used.

Cite This Study

Onaka et al. (1998) studied Hypertension (Spontaneously hypertensive rats). Enalapril or Hydralazine + Hydrochlorothiazide vs. Untreated spontaneously hypertensive rats and Wistar Kyoto rats was evaluated on Acetylcholine-induced hyperpolarization and EDHF-mediated relaxation in the mesenteric artery. Antihypertensive treatment with enalapril or hydralazine/hydrochlorothiazide improved EDHF-mediated maximal relaxation (79.3% and 47.4% vs 4.8%) in the mesenteric artery of hypertensive rats.

synapsesocial.com/papers/6a64d3bf9aeeefc9b8ef480f https://doi.org/10.1161/01.cir.98.2.175

Topics

Hypertension management

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Antihypertensive Treatment Improves Endothelium-Dependent Hyperpolarization in the Mesenteric Artery of Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Antihypertensive Treatment Improves Endothelium-Dependent Hyperpolarization in the Mesenteric Artery of Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider