What question did this study set out to answer?

To evaluate the effect of chronic cilazapril administration on vascular reactivity in the aorta and mesenteric artery of spontaneously hypertensive rats.

September 1, 1995American Journal of Hypertension

Cilazapril reverses endothelium-dependent vasodilator response to acetylcholine in mesenteric artery from spontaneously hypertensive rats*

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Why the study?

Does cilazapril improve acetylcholine-induced relaxation in the aorta and mesenteric artery of spontaneously hypertensive rats?

Population

Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR)

Comparison

Cilazapril 5 mg/kg injected intraperitoneally… vs Untreated WKY rats and untreated SHR

Design

Preclinical

Follow-up

4 weeks

Authors

RYRon-Hua YoungTri-Service General Hospital YDYu‐An DingThe First People's Hospital of Changde YLYen‐Mei LeeNational Defense Medical College

Discussion

Member takes

Implication

Supports endothelial benefits of ACE inhibition in hypertensive models; leaves open translation to human hypertension.

Key Points

To evaluate the effect of chronic cilazapril administration on vascular reactivity in the aorta and mesenteric artery of spontaneously hypertensive rats.
Treated spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats with cilazapril (5 mg/kg intraperitoneally twice daily for 4 weeks).
Assessed acetylcholine-induced vascular relaxation in isolated aorta and mesenteric artery rings.
Tested mechanistic involvement of nitric oxide and other pathways using LNNA, methylene blue, tetraethylammonium, and indomethacin.
Acetylcholine-induced relaxation was significantly reduced in SHR aorta and mesenteric arteries compared to WKY rats, and 4-week cilazapril treatment completely reversed this impairment.
LNNA and methylene blue completely blocked acetylcholine-induced relaxation in the aorta but only partially inhibited relaxation in mesenteric arteries across all groups.
The LNNA- and methylene blue-resistant relaxation in mesenteric arteries was slightly inhibited by tetraethylammonium but remained unaffected by indomethacin.

Structured PICO

Does cilazapril improve acetylcholine-induced relaxation in the aorta and mesenteric artery of spontaneously hypertensive rats?

Population

Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR)

Intervention

Cilazapril 5 mg/kg injected intraperitoneally twice a day for 4 weeks

Comparator

Untreated WKY rats and untreated SHR

Outcome

Acetylcholine (ACh)-induced relaxation in aorta and mesenteric arterysurrogate

Chronic ACE inhibition with cilazapril reverses endothelial dysfunction in spontaneously hypertensive rats, likely by restoring the release of endothelium-dependent relaxing factors.

Cite This Study

Young et al. (1995) studied this question.

synapsesocial.com/papers/6a72bbfbe36a167817e40a96 https://doi.org/10.1016/0895-7061(95)00158-l

Topics

Hypertension management

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Cilazapril reverses endothelium-dependent vasodilator response to acetylcholine in mesenteric artery from spontaneously hypertensive rats*

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Cilazapril reverses endothelium-dependent vasodilator response to acetylcholine in mesenteric artery from spontaneously hypertensive rats*

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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