Why the study?
Does cilazapril prevent hypertension in spontaneously hypertensive rats?
Population
Young spontaneously hypertensive rats (SHR)
Comparison
Cilazapril 10 mg/kg/day p.o. from age 4 to 14… vs Age-matched (14 weeks) control SHR
Design
Preclinical
Follow-up
10 weeks
Authors
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Supports cilazapril in SHR models; leaves open translation to human hypertension therapy.
Does cilazapril prevent hypertension in spontaneously hypertensive rats?
Cilazapril prevents the development of hypertension and cardiac hypertrophy in spontaneously hypertensive rats by reducing peripheral vascular resistance.
Hefti et al. (1986) studied this question.
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