Key result
Cilazapril treatment for 9 weeks decreased the left ventricular weight/body weight ratio (p<0.001) and minimal coronary vascular resistance (p<0.01) in spontaneously hypertensive rats.
Why the study?
Does cilazapril prevent the development of cardiac hypertrophy and the decrease of coronary vascular reserve in spontaneously hypertensive rats?
Population
19 spontaneously hypertensive (SHR) rats
Comparison
Cilazapril 10 mg/kg/day by oral gavage for 9 weeks vs Distilled water
Design
Preclinical
Follow-up
9 weeks
Authors
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Extends ACE inhibitor effects in hypertensive rat models; leaves open human translation pending trials.
Does cilazapril prevent the development of cardiac hypertrophy and the decrease of coronary vascular reserve in spontaneously hypertensive rats?
p-value: p=<0.001
Chronic treatment with the ACE inhibitor cilazapril prevents left ventricular hypertrophy and preserves coronary vascular reserve in a rat model of spontaneous hypertension.
Clozel et al. (1988) studied Hypertension (n=19). Cilazapril vs. Distilled water was evaluated on Left ventricular weight/body weight ratio and minimal coronary vascular resistance (p=<0.001). Cilazapril treatment for 9 weeks decreased the left ventricular weight/body weight ratio (p<0.001) and minimal coronary vascular resistance (p<0.01) in spontaneously hypertensive rats.
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