Why the study?
Does cilazapril improve cerebral vascular reserve in spontaneously hypertensive rats?
Population
36 rats: 24 spontaneously hypertensive rats and 12 Wistar-Kyoto rats
Comparison
Cilazapril 10 mg/kg/day from 14 weeks to 33… vs Placebo
Design
Preclinical
Follow-up
19 weeks (from 14 to 33 weeks of age)
Authors
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ACE inhibition may remodel cerebral vessels in hypertensive models; leaves open human translation.
Does cilazapril improve cerebral vascular reserve in spontaneously hypertensive rats?
Long-term ACE inhibition with cilazapril normalizes cerebral vascular reserve and reduces medial hypertrophy in cerebral vessels of spontaneously hypertensive rats.
Clozel et al. (1989) studied this question.
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