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April 1, 1988Clinical Science

Antihypertensive and renal effects of cilazapril and their reversal by angiotensin in renovascular hypertensive rats

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Population

Two-kidney, one-clip Goldblatt hypertensive rats (n=11) and normotensive rats (n=6)

Comparison

Intravenous infusion of cilazapril with or… vs Normotensive rats and baseline values

Design

Preclinical

Authors

YDYu‐An DingThe First People's Hospital of ChangdeSCShin‐Tsu ChangFu Jen Catholic UniversitySSShyh‐Ming ShiehNational Yang Ming Chiao Tung University

Discussion

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Implication

Supports ACE inhibition mechanisms in rat hypertension models; leaves open human translation.

Structured PICO

P
Population
Two-kidney, one-clip Goldblatt hypertensive rats (n=11) and normotensive rats (n=6)
I
Intervention
Intravenous infusion of cilazapril (1 mg/kg followed by 25 micrograms min-1 kg-1) with or without superimposed administration of angiotensin II or angiotensin III
C
Comparator
Normotensive rats and baseline values
O
Outcome
Blood pressure and renal function (glomerular filtration rate, urine flow, absolute and fractional excretion rates of sodium and potassium)surrogate

Cilazapril reduces arterial pressure and enhances renal excretion in renovascular hypertensive rats primarily via inhibition of angiotensin II and III formation.

Cite This Study

Ding et al. (1988) studied this question.

synapsesocial.com/papers/6a815ab76a18bae044690d0dhttps://doi.org/10.1042/cs0740365
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ANGIOTENSIN‐CONVERTING ENZYME INHIBITION CAUSES DETERIORATION IN RENAL FUNCTION IN ONE‐KIDNEY GOLDBLATT HYPERTENSIVE RATS WITH AND WITHOUT RENAL ARTERIAL STENOSIS1992 · 3 citations
  2. 2Effects of acute and chronic cilazapril treatment in spontaneously hypertensive rats.1989 · 23 citations
  3. 3Effects of Chronic Therapy with Cilazapril, a New Angiotensin-Converting Enzyme Inhibitor, on Regional Blood Flows in Conscious Spontaneously Hypertensive Rats1987 · 10 citations
  4. 4Cilazapril Prevents Hypertension in Spontaneously Hypertensive Rats1986 · 37 citations
  5. 5Antihypertensive Effects and Pharmacokinetics of Single and Consecutive Doses of Cilazapril in Hypertensive Patients with Normal and Impaired Renal Function1988 · 29 citations