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February 1, 1988Journal of Cardiovascular Pharmacology

Antihypertensive Effects and Pharmacokinetics of Single and Consecutive Doses of Cilazapril in Hypertensive Patients with Normal and Impaired Renal Function

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Why the study?

Does cilazapril effectively lower blood pressure and how do its pharmacokinetics differ in hypertensive patients with normal versus impaired renal function?

Population

12 hypertensive patients, including 5 with normal renal function and 7 with impaired renal function.

Design

Cohort

Follow-up

5 or 8 days

Authors

HSHiroshi ShionoiriYokohama City UniversityEGEiji GotohYokohama City UniversityNTNobuyoshi TakagiYokohama City University

Discussion

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Implication

May support cilazapril for BP control across renal function; leaves open dosing guidance and safety in impairment.

Structured PICO

Does cilazapril effectively lower blood pressure and how do its pharmacokinetics differ in hypertensive patients with normal versus impaired renal function?

P
Population
12 hypertensive patients, including 5 with normal renal function (NRF) and 7 with impaired renal function (IRF).
I
Intervention
Cilazapril 1.25 mg orally once a day for 5 or 8 days.
O
Outcome
Blood pressure reduction and pharmacokinetic properties (plasma levels, AUC, serum ACE activity).surrogate

Cilazapril provides effective 24-hour blood pressure control in hypertensive patients, though its active metabolite accumulates more in those with impaired renal function.

Cite This Study

Shionoiri et al. (1988) studied this question.

synapsesocial.com/papers/6a8bef7bdbcda37421e9501ehttps://doi.org/10.1097/00005344-198802000-00018

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antihypertensive Effects and Pharmacokinetics of Single and Consecutive Doses of Cilazapril in Hypertensive Patients with Normal and Impaired Renal Function1988 · 2 citations
  2. 2Antihypertensive effects and pharmacokinetics of single and consecutive doses of cilazapril in hypertensive patients with normal or impaired renal function.1989 · 7 citations
  3. 3Pharmacokinetics and haemodynamic effects of the angiotensin converting enzyme inhibitor cilazapril in hypertensive patients with normal and impaired renal function1996 · 2 citations
  4. 4Pharmacokinetics and haemodynamic effects of the angiotensin converting enzyme inhibitor cilazapril in hypertensive patients with normal and impaired renal function1996 · 1 citations
  5. 5Acute Effects of the New Angiotensin‐Converting Enzyme Inhibitor Cilazapril: A Pilot Study1988 · 1 citations