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July 1, 1988The Journal of Clinical Pharmacology

Acute Effects of the New Angiotensin‐Converting Enzyme Inhibitor Cilazapril: A Pilot Study

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Why the study?

Does cilazapril lower blood pressure and suppress plasma ACE levels in hypertensive patients?

Population

12 hypertensive patients

Comparison

Cilazapril oral single daily doses of 5, 10, or… vs Placebo

Design

Other

Follow-up

72 hours

Authors

RMRogério Andrade MulinariUniversidade Federal do ParanáIGIoanna GouniBaylor College of MedicineHGHaralambos GavrasGeneral / Preventive / Lipids

Discussion

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Implication

Supports cilazapril dosing exploration in hypertension; extends pharmacokinetic data but leaves open efficacy pending randomized trials.

Structured PICO

Does cilazapril lower blood pressure and suppress plasma ACE levels in hypertensive patients?

P
Population
12 hypertensive patients
I
Intervention
Cilazapril oral single daily doses of 5, 10, or 20 mg
C
Comparator
Placebo (each active dose was preceded and followed by two placebo days)
O
Outcome
Magnitude and duration of action on blood pressure and plasma ACE levelssurrogate

Cilazapril at 5-10 mg daily provides maximal acute blood pressure lowering and ACE suppression in hypertensive patients.

Limitations

  • long-term dose trials are necessary to establish its clinical utility

Cite This Study

Mulinari et al. (1988) studied this question.

synapsesocial.com/papers/6a8bcbc690fae8fd47e993c7https://doi.org/10.1002/j.1552-4604.1988.tb03194.x

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pilot Study of the Effects of the Angiotensin‐Converting Enzyme Inhibitor CI‐906 on Patients with Essential Hypertension1984 · 20 citations
  2. 2Captopril in the Treatment of Hypertension1981 · 11 citations
  3. 3Antihypertensive Effect of the Oral Angiotensin Converting-Enzyme Inhibitor SQ 14225 in Man1978 · 604 citations
  4. 4The Effects of Antihypertensive Therapy on the Quality of Life1986 · 1,337 citations
  5. 5Differences in response to the peptidyldipeptide hydrolase inhibitors SQ 20,881 and SQ 14,225 in normal-renin essential hypertension.1980 · 31 citations