Key result
The selective ETA receptor blocker A-127722 did not significantly reduce systolic pressure compared to control (164 vs 177 mmHg) in 2K-1C renovascular hypertensive rats.
Why the study?
Does selective ETA receptor blockade improve arterial pressure and renal hemodynamics in 2K-1C renovascular hypertensive rats?
Population
31 two-kidney, one-clip (2K-1C) Goldblatt renovascular hypertensive rats
Comparison
Selective ETA receptor blocker given orally at a… vs Control group (presumably untreated or vehicle)
Design
Preclinical
Follow-up
3 weeks
Authors
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Does not support selective ETA blockade for BP reduction; leaves open its role in renal hemodynamics of renovascular hypertension.
Does selective ETA receptor blockade improve arterial pressure and renal hemodynamics in 2K-1C renovascular hypertensive rats?
Absolute Event Rate: 164% vs 177%
p-value: p=not statistically different
ETA receptors play an important role in altering renal hemodynamics of the unclipped kidney in severe renovascular hypertension, but do not appear to drive the progression of the hypertension itself.
Kassab et al. (2001) studied 2K-1C renovascular hypertension (n=31). Selective ETA receptor blocker (A-127722) vs. Control was evaluated on Systolic pressure (p=not statistically different). The selective ETA receptor blocker A-127722 did not significantly reduce systolic pressure compared to control (164 vs 177 mmHg) in 2K-1C renovascular hypertensive rats.
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