Key result
Renal artery clipping increases renal ET-1 tissue concentration ~2-fold compared to sham operation.
Why the study?
The activation status of the renal endothelin system in the two-kidney, one clip model of renovascular hypertension was unclear.
Does renal artery clipping activate the renal endothelin system in the two-kidney, one clip rat model of renovascular hypertension?
Population
9-week-old Wistar Kyoto rats
Comparison
Renal artery clipping vs sham operation
Design
Randomized controlled preclinical study
Follow-up
10 days and 12 weeks
Authors
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Supports time-dependent renal ET-1 activation in 2K1C rats; leaves open any role in human renovascular hypertension.
RCT
randomly assigned
Does renal artery clipping activate the renal endothelin system in the two-kidney, one clip rat model of renovascular hypertension?
Absolute Event Rate: 25.6% vs 12.5%
p-value: p=<0.05
In the 2K1C rat model of renovascular hypertension, the renal endothelin system is activated in a time- and condition-dependent manner, suggesting a synergistic activation via increased ET-1 and upregulated ET(A)-receptors.
Diekmann et al. (2000) conducted an RCT in Renovascular hypertension. Renal artery clipping vs. Sham operation was evaluated on Immunoreactive ET-1 tissue concentration in the renal cortex of the nonclipped kidney at 10 days (pg/g) (p=<0.05). Renal artery clipping significantly increased ET-1 tissue concentration (25.6 vs 12.5 pg/g; p<0.05) and ET(A)-receptor density in the kidneys compared to sham operation.
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