Why the study?
Does the endothelin antagonist Ro 47-0203 alter renin secretion and gene expression in normal and hypoperfused rat kidneys?
Population
Normal rats, rats with unilateral renal artery clips (0.2 mm), and isolated perfused rat kidneys
Comparison
Endothelin antagonist Ro 47-0203 vs Untreated controls
Design
Preclinical
Follow-up
2 days
Authors
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Supports lack of endothelin role in renin control in rat renal hypoperfusion; leaves open human relevance.
Does the endothelin antagonist Ro 47-0203 alter renin secretion and gene expression in normal and hypoperfused rat kidneys?
Endogenous endothelins do not appear to play a relevant role in controlling renin secretion and gene expression in normal and hypoperfused rat kidneys.
Schricker et al. (1995) studied this question.
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