Why the study?
Does blocking endothelium-derived NO with L-NAME inhibit pressure-dependent renin release in conscious dogs?
Population
Six conscious foxhounds with chronically implanted catheters in the abdominal aorta and the renal vein
Comparison
NG-nitro-L-arginine methyl ester 1,000 mg bolus vs Control (baseline before L-NAME administration)
Design
Preclinical
Authors
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Implicates NO in pressure-dependent renin release in dogs; leaves open translation to human renovascular disease.
Does blocking endothelium-derived NO with L-NAME inhibit pressure-dependent renin release in conscious dogs?
Blocking endothelium-derived NO with L-NAME significantly attenuates pressure-dependent renin release in conscious dogs, particularly at low renal artery pressures.
Persson et al. (1993) studied this question.
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