Population
Conscious chronically instrumented dogs (n=7)
Comparison
Intrarenal infusion of Nitro-L-arginine methyl… vs Intravenous infusion of L-NAME at 10…
Design
Preclinical
Follow-up
180 min
Authors
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Extrarenal mechanisms predominate in systemic NO blockade effects on renal hemodynamics; leaves open selective intrarenal NO modulation in human disease.
Systemic NO synthesis blockade affects renal hemodynamics largely through extrarenal mechanisms, likely via sympathetic nervous system activation, rather than direct intrarenal effects.
Granger et al. (1992) studied this question.
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