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March 1, 1997AJP Regulatory Integrative and Comparative Physiology

Inhibition of intrarenal NO stimulates renin secretion through a macula densa-mediated mechanism

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Why the study?

Does intrarenal NO synthesis inhibition increase renin secretion rate via a macula densa-mediated mechanism in dogs?

Population

Dogs with normal kidney function and dogs with the macula densa mechanism blocked (nonfiltering kidney model)

Comparison

N-nitro-L-arginine methyl ester administered via… vs Dogs with the macula densa mechanism blocked

Design

Preclinical

Authors

CSChristine G. SchnackenbergGlaxoSmithKline (United States)BTBarbara TaborChildren's Hospital of PhiladelphiaMSMolly StrongUniversity of Kentucky

Discussion

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Implication

Highlights macula densa mediation in canine renin regulation; leaves open translation to clinical NO modulation in kidney disease.

Structured PICO

Does intrarenal NO synthesis inhibition increase renin secretion rate via a macula densa-mediated mechanism in dogs?

P
Population
Dogs with normal kidney function and dogs with the macula densa mechanism blocked (nonfiltering kidney model)
I
Intervention
N(omega)-nitro-L-arginine methyl ester (L-NAME) administered via the renal artery at 5 microg x kg(-1) x min(-1)
C
Comparator
Dogs with the macula densa mechanism blocked (nonfiltering kidney model)
O
Outcome
Renin secretion rate (RSR)surrogate

Intrarenal NO synthesis blockade enhances renin secretion in dogs, an effect that is primarily mediated by the macula densa mechanism.

Cite This Study

Schnackenberg et al. (1997) studied this question.

synapsesocial.com/papers/6a7ebfb2a390b11a0aa6c7fehttps://doi.org/10.1152/ajpregu.1997.272.3.r879
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Control of Renal Hemodynamics During Intrarenal and Systemic Blockade of Nitric Oxide Synthesis in Conscious Dogs1992 · 86 citations
  2. 2Evidence for the role of nitric oxide in macula densa control of glomerular hemodynamics.1993 · 196 citations
  3. 3Effect of nitric oxide on renin secretion. II. Studies in the perfused juxtaglomerular apparatus1995 · 65 citations
  4. 4Endothelium-derived relaxing factor regulates renin release in vivo1992 · 90 citations
  5. 5NG-methyl-L-arginine, an inhibitor of L-arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo. A role for nitric oxide in the central regulation of sympathetic tone?1992 · 387 citations