Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1993AJP Renal Physiology

Inhibition of nitric oxide synthesis attenuates pressure-induced natriuretic responses in anesthetized dogs

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does intrarenal infusion of nitro-L-arginine alter pressure-induced natriuretic responses in anesthetized dogs?

Population

20 anesthetized dogs (11 in main group, 9 treated with the angiotensin receptor antagonist losartan)

Comparison

Intrarenal infusion of nitro-L-arginine at 50… vs Baseline (before intrarenal infusion of NLA)

Design

Preclinical

Authors

DMDewan S. A. MajidTulane UniversityAWAleck F. WilliamsMidlands Technical CollegeLNL. Gabriel NavarVascular Medicine

Discussion

Loading...

Member takes

Implication

Supports nitric oxide in pressure-natriuresis; leaves open human translation from canine models.

Structured PICO

Does intrarenal infusion of nitro-L-arginine alter pressure-induced natriuretic responses in anesthetized dogs?

P
Population
20 anesthetized dogs (11 in main group, 9 treated with the angiotensin receptor antagonist losartan)
I
Intervention
Intrarenal infusion of nitro-L-arginine (NLA) at 50 micrograms.kg-1.min-1
C
Comparator
Baseline (before intrarenal infusion of NLA)
O
Outcome
Ability of the kidney to alter its sodium excretion in response to acute changes in renal arterial pressure (RAP)surrogate

Nitric oxide appears to participate in mediating the pressure-natriuresis response in the kidney, independent of the renin-angiotensin system.

Cite This Study

Majid et al. (1993) studied this question.

synapsesocial.com/papers/6a88eb0c58d99da5144d25eahttps://doi.org/10.1152/ajprenal.1993.264.1.f79
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renal responses to intra-arterial administration of nitric oxide donor in dogs.1993 · 88 citations
  2. 2Responses to Acute Changes in Arterial Pressure on Renal Medullary Nitric Oxide Activity in Dogs1999 · 20 citations
  3. 3Suppression of blood flow autoregulation plateau during nitric oxide blockade in canine kidney1992 · 113 citations
  4. 4Intrarenal Nitric Oxide Activity and Pressure Natriuresis in Anesthetized Dogs1998 · 63 citations
  5. 5Inhibition of intrarenal NO stimulates renin secretion through a macula densa-mediated mechanism1997 · 38 citations