February 1, 1995Clinical and Experimental Pharmacology and Physiology
EFFECTS OF NG‐NITRO‐l‐ARGININE ON PRESSURE NATRIURESIS IN ANAESTHETIZED RABBITS
Population
16 pentobarbitone-anaesthetized rabbits
Comparison
NG-nitro-L-arginine (NOLA, 20 mg/kg, i.v.) vs Vehicle
Design
Preclinical
Follow-up
Five 30-minute experimental periods
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for nitric oxide's role in renal hemodynamics; leaves open translation to human hypertension or kidney disease.
Structured PICO
P
Population
16 pentobarbitone-anaesthetized rabbits
I
Intervention
NG-nitro-L-arginine (NOLA, 20 mg/kg, i.v.)
C
Comparator
Vehicle
O
Outcome
Renal blood flow, filtration fraction, glomerular filtration rate, and sodium excretion across varying renal artery pressures (65, 80, 95, 110, and 130 mmHg)surrogate
Inhibition of nitric oxide synthesis with NOLA in anaesthetized rabbits causes profound renal vasoconstriction and blunts pressure natriuresis, suggesting endogenous nitric oxide tonically dilates renal vasculature and enhances sodium excretion.
Cite This Study
Evans et al. (1995) studied this question.