Why the study?
Does Nw-nitro-L-arginine (L-NNA) alter hindquarter hemodynamics and vascular responses in conscious rabbits?
Population
Conscious rabbits
Comparison
Nw-nitro-L-arginine 16 mg/kg/h i.v. on days 1… vs Vehicle on day 0
Design
Preclinical
Follow-up
7 days
Authors
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Preclinical rabbit data warrant no clinical translation; extends evidence for NO-independent hyperemia while leaving long-term pressure regulation unresolved.
Does Nw-nitro-L-arginine (L-NNA) alter hindquarter hemodynamics and vascular responses in conscious rabbits?
Inhibition of nitric oxide synthase by L-NNA in conscious rabbits demonstrates that reactive hyperemia is independent of NO and that basal NO release regulates short-term but not long-term arterial pressure.
Ward et al. (1993) studied this question.
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