Why the study?
Does acute inhibition of nitric oxide synthesis by L-NAME alter cardiovascular responses differently when peripheral autonomic activity is blocked compared to when it is intact in anaesthetized rabbits?
Population
Anaesthetized rabbits
Comparison
Intravenous L-NAME following peripheral… vs Intravenous L-NAME with intact autonomic nervous…
Design
Preclinical
Authors
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L-NAME pressor effects persist despite autonomic blockade; leaves open humoral contributions to chronotropic responses in nitric oxide inhibition.
Does acute inhibition of nitric oxide synthesis by L-NAME alter cardiovascular responses differently when peripheral autonomic activity is blocked compared to when it is intact in anaesthetized rabbits?
L-NAME-induced hypertension does not rely solely on the autonomic nervous system, and its chronotropic effects involve other humoral mechanisms when autonomic activity is completely blocked.
Ehab S ELDesoky (2006) studied this question.
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