Key result
Acute nitric oxide synthase inhibition with L-NAME promoted a tachycardic response in rats with complete autonomic blockade (P<0.05 vs intact animals), suggesting humoral mechanism involvement.
Population
Anesthetized intact rats, rats submitted to partial and complete autonomic blockade, and isolated rat atria
Comparison
Acute nitric oxide synthase inhibition with N… vs Intact rats vs. rats with partial or complete…
Design
Preclinical
Authors
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Supports humoral modulation of heart rate after NOS inhibition; hypothesis-generating and requires human validation before clinical consideration.
Acute nitric oxide synthase inhibition with L-NAME induces tachycardia in rats with complete autonomic blockade but not in isolated atria, suggesting humoral mechanisms modulate the cardiac response.
Fellet et al. (2003) studied Anesthetized intact rats and rats submitted to partial and complete autonomic blockade. N G-nitro-L-arginine methyl ester (L-NAME) vs. Intact rats was evaluated on Blood pressure and heart rate. Acute nitric oxide synthase inhibition with L-NAME promoted a tachycardic response in rats with complete autonomic blockade (P<0.05 vs intact animals), suggesting humoral mechanism involvement.