Why the study?
Does N-nitro-L-arginine alter mean arterial pressure, hindlimb vascular resistance, and heart rate in conscious rabbits?
Population
Conscious rabbits
Comparison
N-nitro-L-arginine (NOLA) 15 mg/kg i.v. vs Baseline/control levels, and response in the…
Design
Preclinical
Follow-up
72 hours
Authors
Loading...
Should not change clinical practice; leaves open sustained NO inhibition effects on human hemodynamics.
Does N-nitro-L-arginine alter mean arterial pressure, hindlimb vascular resistance, and heart rate in conscious rabbits?
Inhibition of nitric oxide synthesis with NOLA causes prolonged vasoconstriction and hypertension in conscious rabbits, highlighting the role of peripheral NO in regulating vascular tone.
Du et al. (1991) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: