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July 1, 1992Clinical and Experimental Pharmacology and Physiology

Inhibition of Nitric Oxide Synthase Specifically Enhances Adrenergic Vasoconstriction in Rabbits

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Why the study?

Does inhibition of nitric oxide synthase with NOLA alter vascular tone and responses to vasoactive agents in rabbits?

Population

Conscious rabbits (autonomically blocked) and rabbit isolated aortae

Comparison

N-nitro-L-arginine vs Baseline/control responses prior to NOLA…

Design

Preclinical

Authors

ZDZ. Y. DuThe University of MelbourneGDG. J. DustingThe University of MelbourneOWOwen L. WoodmanVascular / Pulmonary Vascular

Discussion

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Implication

Supports nitric oxide's role in basal vascular tone in rabbits; leaves open translation to human endothelial or hypertensive disorders.

Structured PICO

Does inhibition of nitric oxide synthase with NOLA alter vascular tone and responses to vasoactive agents in rabbits?

P
Population
Conscious rabbits (autonomically blocked) and rabbit isolated aortae
I
Intervention
N-nitro-L-arginine (NOLA) (15 mg/kg intravenous infusion in vivo; 10 mumol/L in vitro)
C
Comparator
Baseline/control responses prior to NOLA administration
O
Outcome
Arterial pressure, hindlimb vascular resistance, and vascular responses to vasoactive agents (acetylcholine, glyceryl trinitrate, noradrenaline, tyramine, phenylephrine, U46619)surrogate

Inhibition of nitric oxide synthase with NOLA causes systemic vasoconstriction and specifically enhances adrenergic vasoconstriction, highlighting the role of nitric oxide in regulating normal vascular tone.

Cite This Study

Du et al. (1992) studied this question.

synapsesocial.com/papers/6a88eb9d30fc94fc4b130b27https://doi.org/10.1111/j.1440-1681.1992.tb00499.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acetylcholine-induced vasodilatation in rabbit hindlimb in vivo is not inhibited by analogues of L-arginine1991 · 74 citations
  2. 2N‐nitro <scp>l</scp>‐arginine causes coronary vasoconstriction and inhibits endothelium‐dependent vasodilatation in anaesthetized greyhounds1991 · 49 citations
  3. 3Effect of endothelium removal on the vasoconstrictor response to neuronally released 5‐hydroxytryptamine and noradrenaline in the rat isolated mesenteric and femoral arteries1991 · 39 citations
  4. 4Role of endothelium in the contractile response of rat aorta to α-adrenoceptor agonists1985 · 100 citations
  5. 5Endothelium and control of vascular function. State of the Art lecture.1989 · 672 citations