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August 1, 1998Hypertension

Intrarenal Nitric Oxide Activity and Pressure Natriuresis in Anesthetized Dogs

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Population

Anesthetized dogs

Design

Preclinical

Authors

DMDewan S. A. MajidTulane UniversitySOSophia A. OmoroTulane UniversitySCSo Yeon ChinTulane University

Discussion

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Implication

Hypothesis-generating for intrarenal NO in pressure-natriuresis; leaves open relevance to human hypertension.

Structured PICO

P
Population
Anesthetized dogs (n=7 for nitro-L-arginine, n=5 for SNAP infusion, n=10 for graded reductions of renal arterial pressure)
I
Intervention
Intrarenal nitro-L-arginine (50 microg/kg/min), SNAP infusions (1, 2, and 3 microg/kg/min), and graded reductions of renal arterial pressure
O
Outcome
Changes in renal tissue NO activities, urinary excretion rates of NO metabolites (nitrates and nitrites), and sodiumsurrogate

Acute changes in renal arterial pressure result in alterations in intrarenal NO activity, which may mediate the associated changes in sodium excretion.

Cite This Study

Majid et al. (1998) studied this question.

synapsesocial.com/papers/6a7210b0febe604dd70a6bc9https://doi.org/10.1161/01.hyp.32.2.266
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of nitric oxide in regulation of long-term pressure-natriuresis relationship in Dahl rats1995 · 107 citations
  2. 2NITRIC OXIDE, THE KIDNEY AND HYPERTENSION1997 · 30 citations
  3. 3Localization and regulation of endothelial NO synthase mRNA expression in rat kidney1994 · 144 citations
  4. 4Nitric oxide synthase in macula densa regulates glomerular capillary pressure.1992 · 529 citations
  5. 5Role of calcium and calmodulin in flow-induced nitric oxide production in endothelial cells1994 · 521 citations