Why the study?
Does nitric oxide synthesis inhibition alter renal hemodynamics and urinary sodium excretion in conscious dogs?
Population
7 conscious dogs equipped with indwelling vascular catheters and an electromagnetic flow probe on the iliac…
Comparison
Continuous intravenous infusion of… vs Control period
Design
Preclinical
Follow-up
25 days
Authors
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Supports nitric oxide's role in canine renal control; leaves open translation to human hypertension.
Does nitric oxide synthesis inhibition alter renal hemodynamics and urinary sodium excretion in conscious dogs?
Nitric oxide plays a critical long-term role in controlling renal hemodynamics and mediating the relationship between arterial pressure and urinary sodium excretion.
Manning et al. (1994) studied this question.
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