Why the study?
Does inhibition of prostaglandins or nitric oxide reduce macula densa-dependent activation of the renin system in male Sprague-Dawley rats?
Population
Male Sprague-Dawley rats
Comparison
Indomethacin or nitro-L-arginine methyl ester… vs Furosemide infusion alone
Design
Preclinical
Follow-up
6 days
Authors
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Should not change clinical practice; supports NO/prostaglandin dependence of macula densa renin activation in rats.
Does inhibition of prostaglandins or nitric oxide reduce macula densa-dependent activation of the renin system in male Sprague-Dawley rats?
Activation of renin gene expression by macula densa blockade depends on intact NO and prostaglandin formation, while renin secretion mainly requires intact NO formation.
Schricker et al. (1995) studied this question.
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