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August 1, 1993Journal of Clinical InvestigationOpen Access

Evidence for the role of nitric oxide in macula densa control of glomerular hemodynamics.

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Why the study?

Does L-NAME alter afferent arteriolar constriction induced by NaCl concentrations at the macula densa in rabbit kidney models?

Population

In vitro microperfusions of rabbit afferent arterioles and adherent tubular segments, n=10

Comparison

Nw-nitro-L-arginine methyl ester 10 M added to a… vs Low NaCl vs high NaCl perfusate without L-NAME…

Design

Preclinical

Authors

SISadayoshi ItoVascular MedicineYRYufeng RenSun Yat-sen University

Discussion

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Overview

Supports macula densa-derived NO modulation of afferent tone in rabbits; hypothesis-generating, should not yet inform practice.

Structured PICO

Does L-NAME alter afferent arteriolar constriction induced by NaCl concentrations at the macula densa in rabbit kidney models?

P
Population
In vitro microperfusions of rabbit afferent arterioles (with the glomerulus intact) and adherent tubular segments (thick ascending limb, macula densa, and early distal tubule), n=10
I
Intervention
Nw-nitro-L-arginine methyl ester (L-NAME) 10(-5) M added to a macula densa perfusate
C
Comparator
Low NaCl vs high NaCl perfusate without L-NAME, and reversal with L-arginine vs D-arginine
O
Outcome
Diameter of the afferent arteriolessurrogate

The macula densa may produce nitric oxide, which modulates afferent arteriolar constriction induced by high concentrations of NaCl.

Cite This Study

Ito et al. (1993) studied this question.

synapsesocial.com/papers/6a1ec40dbf2a5d44faaf4ac2https://doi.org/10.1172/jci116615
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nitric oxide synthase in macula densa regulates glomerular capillary pressure.1992 · 529 citations
  2. 2Modulation of angiotensin II-induced vasoconstriction by endothelium-derived relaxing factor in the isolated microperfused rabbit afferent arteriole.1991 · 215 citations
  3. 3Endothelium-derived relaxing factor modulates endothelin action in afferent arterioles.1991 · 81 citations
  4. 4Endothelium-derived relaxing factor inhibits transport and increases cGMP content in cultured mouse cortical collecting duct cells.1992 · 125 citations
  5. 5Role of the endothelium-dependent relaxing factor nitric oxide on renal function.1992 · 160 citations