June 1, 1995Journal of Cardiovascular Pharmacology

Nitric Oxide Synthase Blockade and Renal Vascular Responses to Norepinephrine and Endothelin-1 in Conscious Dogs

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Why the study?

Does nitric oxide synthase blockade alter renal vascular responses to norepinephrine and endothelin-1 in conscious dogs?

Population

Conscious dogs (n=5 for norepinephrine infusion experiment, n=5 for endothelin-1 infusion experiment)

Comparison

Pretreatment with nitric oxide synthase… vs Pretreatment with vehicle, followed by…

Design

Preclinical

Follow-up

Acute

Authors

SFSharyn M. FitzgeraldNorthwestern University RERoger G. EvansGeneral Cardiology ICIrene J. ChristyBaker Heart and Diabetes Institute

Discussion

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Implication

Suggests selective nitric oxide buffering of norepinephrine renal vasoconstriction in dogs; hypothesis-generating and leaves open human translation.

Structured PICO

Does nitric oxide synthase blockade alter renal vascular responses to norepinephrine and endothelin-1 in conscious dogs?

Population

Conscious dogs (n=5 for norepinephrine infusion experiment, n=5 for endothelin-1 infusion experiment)

Intervention

Pretreatment with nitric oxide synthase inhibitor NG-nitro-L-arginine (L-NNA) 10 mg/kg intravenously, followed by intrarenal infusion of norepinephrine (0.02-0.2 micrograms/kg/min) or endothelin-1 (2.7 ng/kg/min)

Comparator

Pretreatment with vehicle (250 mM NaHCO3 solution at 2 ml/kg intravenously), followed by intrarenal infusion of norepinephrine or endothelin-1

Outcome

Changes in renal blood flow (RBF) and renal vascular conductancesurrogate

Nitric oxide appears to selectively buffer the renal vasoconstrictor effects of norepinephrine, but this buffering effect does not generalize to endothelin-1.

Cite This Study

Fitzgerald et al. (1995) studied this question.

synapsesocial.com/papers/6a86ae2fc026610cc182a5bd https://doi.org/10.1097/00005344-199506000-00018

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Implication

Suggests selective nitric oxide buffering of norepinephrine renal vasoconstriction in dogs; hypothesis-generating and leaves open human translation.

Nitric Oxide Synthase Blockade and Renal Vascular Responses to Norepinephrine and Endothelin-1 in Conscious Dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Nitric Oxide Synthase Blockade and Renal Vascular Responses to Norepinephrine and Endothelin-1 in Conscious Dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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