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August 1, 1992AJP Renal Physiology

Endothelium-derived relaxing factor regulates renin release in vivo

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Why the study?

Does EDRF synthesis inhibition with L-NAME affect plasma renin activity in intact rats?

Population

Intact anesthetized rats (n=12 per experiment)

Comparison

L-N omega-nitroarginine methyl ester 10 mg/kg… vs Baseline measurements before L-NAME administration

Design

Preclinical

Follow-up

Acute (immediate post-bolus)

Authors

DSDavid H. SigmonTulane UniversityOCOscar A. CarreteroGeneral / Preventive / LipidsWBW. H. BeierwaltesWest Virginia University

Discussion

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Implication

EDRF/NO inhibition stimulates renin secretion in controlled rat models; extends mechanistic insights but leaves open human relevance.

Structured PICO

Does EDRF synthesis inhibition with L-NAME affect plasma renin activity in intact rats?

P
Population
Intact anesthetized rats (n=12 per experiment)
I
Intervention
L-N omega-nitroarginine methyl ester (L-NAME) 10 mg/kg body wt bolus (EDRF synthesis inhibition), with or without intra-aortic balloon catheter and propranolol pretreatment
C
Comparator
Baseline measurements before L-NAME administration
O
Outcome
Plasma renin activity (PRA)surrogate

EDRF synthesis inhibition stimulates renin secretion in vivo when the confounding effects of blood pressure and sympathetic activity are controlled.

Cite This Study

Sigmon et al. (1992) studied this question.

synapsesocial.com/papers/6a81f4e1ac3bbfe76d610151https://doi.org/10.1152/ajprenal.1992.263.2.f256
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelial derived relaxing factor controls renal hemodynamics in the normal rat kidney.1990 · 292 citations
  2. 2Influence of endothelium-derived relaxing factor on renal microvessels and pressure-dependent vasodilation1993 · 51 citations
  3. 3Plasma renin activity and the renal response to nitric oxide synthesis inhibition.1992 · 52 citations
  4. 4Angiotensin dependence of endothelium-mediated renal hemodynamics.1992 · 94 citations
  5. 5Endothelium-derived NO stimulates pressure-dependent renin release in conscious dogs1993 · 87 citations