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January 1, 1989Journal of Hypertension

The effects of endothelin on renovascular resistance and renin release

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Population

Isolated perfused rat kidney

Design

Preclinical

Authors

KMKlaus MünterBayer (Germany)EHE. HackenthalHeidelberg University

Discussion

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Implication

Does not support clinical use; leaves open endothelin's calcium-PKC role in human renin regulation.

Structured PICO

P
Population
Isolated perfused rat kidney
I
Intervention
Endothelin (with or without nimodipine or staurosporine)
O
Outcome
Renin release and renal perfusate flowsurrogate

Endothelin acts via calcium entry and protein kinase C to inhibit renin release and increase renovascular resistance in the isolated rat kidney.

Cite This Study

Münter et al. (1989) studied this question.

synapsesocial.com/papers/6a86ad80241d06231dbee87fhttps://doi.org/10.1097/00004872-198900076-00134
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelin-Induced Renal Vasoconstriction and Increase in Cytosolic Calcium in Renal Vascular Smooth Muscle Cells1990 · 21 citations
  2. 2Natiuretic and Diuretic Effects of Endothelin in Isolated Perfused Rat Kidney.1989 · 7 citations
  3. 3The pharmacological properties of the peptide, endothelin1989 · 99 citations
  4. 4Inhibitory effect of endothelin on renin release in vitro1989 · 34 citations
  5. 5Effects of endothelins on renin secretion from rat kidneys1995 · 22 citations