Population
Collagenase-dispersed rat renal cortical cells and renal cortical slices in a dynamic superfusion system
Comparison
Endothelin (10^-10 M and 10^-8 M) vs Control conditions
Design
Preclinical
Authors
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Endothelin effects on renin merit in vivo validation; leaves open relevance to human hypertension or heart failure.
Endothelin inhibits renin release from juxtaglomerular cells through both calcium influx via dihydropyridine-insensitive channels and mechanisms independent of extracellular calcium.
Takagi et al. (1989) studied this question.
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