Why the study?
Does endothelin inhibit renin release in dog kidneys?
Population
Barbiturate-anaesthetized dogs with denervated kidneys
Comparison
Intrarenal infusion of endothelin vs Baseline state before endothelin infusion
Design
Preclinical
Authors
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Suggests endothelin inhibits renin in dogs; leaves open its role in human renin-angiotensin regulation.
Does endothelin inhibit renin release in dog kidneys?
Endothelin directly inhibits renin release from juxtaglomerular cells in dog kidneys, regardless of whether release is stimulated by prostaglandins or beta-adrenergic activity.
Næss et al. (1993) studied this question.