Why the study?
Does endothelin infusion alter renal blood flow, blood pressure, and glomerular filtration rate in anesthetized dogs and rats?
Population
Pentobarbital-anesthetized dogs (n=11) and pentobarbital-anesthetized female rats (n=16)
Comparison
Endothelin infusion alone or with angiotensin II… vs Baseline control or endothelin alone
Design
Preclinical
Follow-up
Up to 30 minutes post-infusion
Authors
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Endothelin renal effects attenuated by captopril in rats; leaves open kinin pathway relevance for human renal hemodynamics.
Does endothelin infusion alter renal blood flow, blood pressure, and glomerular filtration rate in anesthetized dogs and rats?
Endothelin is a potent renal vasoconstrictor with transient vasodilator effects, and its renal actions may be attenuated by inhibition of kinin degradation via captopril.
R. O. Banks (1990) studied this question.
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