Population
Cultured mouse renal juxtaglomerular (JG) cells
Comparison
Endothelin (ET)-1, ET-2, and ET-3 vs Basal conditions and various receptor…
Design
Preclinical
Authors
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May suppress renin via ETB in rodent JG cells; leaves open translation to human renin-angiotensin regulation or endothelin blockade.
Endothelins selectively inhibit cAMP-activated renin secretion in mouse juxtaglomerular cells via ETB receptors and a calcium-sensitive process.
Ritthaler et al. (1995) studied this question.
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