Population
Isolated rat kidneys perfused at constant renal artery pressure (80 mmHG)
Comparison
Endothelins at concentrations of 10 pmol/L to 1… vs Control conditions
Design
Preclinical
Authors
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ETB-mediated renin inhibition in rat kidneys; hypothesis-generating for human renovascular ET signaling, pending in vivo confirmation.
Endothelins inhibit renin secretion from isolated rat kidneys primarily through ETB receptors involving a calcium-dependent mechanism.
Scholz et al. (1995) studied this question.
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