Population
Conscious and almost unrestrained rats in vivo, and monolayers of renal vascular smooth muscle cells in…
Design
Preclinical
Follow-up
20 minutes
Authors
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Endothelin-driven renal vasoconstriction in animals warrants clinical caution in extrapolation; leaves open its contribution to human hypertensive renal disease.
Endothelin acts as a potent renal vasoconstrictor and increases intracellular calcium in renal vascular smooth muscle cells primarily via extracellular calcium influx.
Murakawa et al. (1990) studied this question.
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